PROTAC BRD4 Degrader-1

Overview

PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC 50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression. (Pink: BRD4 BD1 ligand ( HY-150941 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker ( HY-108369 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-133131
• CAS No.: 2133360-00-4
• Molecular Formula: C40H37N9O8
• Molecular Weight: 771.78
• Purity: 99.31%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (6.48 mM); Clear solution
• Availability: In-stock

Source

Original product source