Pomalidomide-C3-adavosertib

Overview

Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader ( IC 50 =3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis . (Pink: Wee1 ligand ( HY-10993 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-W011561 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Wee1 | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-133618
• CAS No.: 2414418-49-6
• Molecular Formula: C42H45N11O6
• Molecular Weight: 799.88
• Purity: 99.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (1.56 mM); Clear solution
• Availability: In-stock

Source

Original product source