Capmatinib

Overview

Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT , FAK , GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis . Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase.

Application

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Product Information

• Catalog No.: HY-13404
• CAS No.: 1029712-80-8
• Molecular Formula: C23H17FN6O
• Molecular Weight: 412.42
• Purity: 99.71%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 10 mg/mL (24.25 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source