Apostatin-1

Overview

Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N ( K D =2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1 . Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein , or huntingtin .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Beclin1 | Products > Signaling Pathways > Necroptosis

Product Information

• Catalog No.: HY-134050
• CAS No.: 2559703-06-7
• Molecular Formula: C19H27N3OS
• Molecular Weight: 345.50
• Purity: 99.64%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution
• Availability: In-stock

Source

Original product source