N-Methyl Leukotriene C4

Overview

N-Methyl Leukotriene C4 (N-Methyl-LTC4) is a non-metabolizable LTC4 analog and a selective cysteinyl leukotriene receptor 2 ( CysLT2 ) agonist, with an EC 50 of 46.1 nM for mouse CysLT2 and an EC 50 value of 122.3 nM for human CysLT2. N-Methyl Leukotriene C4 shows low potency against CysLT1. N-Methyl Leukotriene C4 activates human and mouse CysLT2 receptors, triggering calcium signaling, β-arrestin-2 binding to phosphorylated receptors, vascular leakage, hypotension, tachycardia, contraction of guinea pig ileum and trachea, mild bronchoconstriction, as well as hypertension associated with peripheral vasoconstriction. N-Methyl Leukotriene C4 can be used in research on asthma, rhinitis, sinusitis, cerebral inflammation and edema, pulmonary arterial hypertension, and cardiovascular diseases.

Application

Products | Products > Disease Areas > Lower Respiratory Inflammation | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Rhinosinusitis | Products > Disease Areas > Rhinitis | Products > Disease Areas > Asthma | Products > Disease Areas > Pulmonary Hypertension | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Upper Respiratory Inflammation | Products > Disease Areas > Respiratory Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Leukotriene Receptor

Product Information

• Catalog No.: HY-134092
• CAS No.: 131391-65-6
• Molecular Formula: C31H49N3O9S
• Molecular Weight: 639.80
• Purity: 98.1%
• Storage: -80°C
• Availability: In-stock

Source

Original product source