5,6-Dihydro-5-Fluorouracil- 13 C, 15 N 2

Overview

5,6-Dihydro-5-Fluorouracil - 13 C, 15 N 2 (5-DHFU- 13 C, 15 N 2 ) is the 13 C- and 15 N-labeled labeled 5,6-Dihydro-5-Fluorouracil ( HY-134160 ). 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil ( HY-90006 ), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC 50 =13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil ( HY-10533 ) slows tumor growth in a rat colon cancer model.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Nucleoside Antimetabolite/Analog

Product Information

• Catalog No.: HY-134160S
• CAS No.: 1189492-99-6
• Molecular Formula: C313CH5F15N2O2
• Molecular Weight: 135.07
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source