JNJ-54717793

Overview

JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC 50 =85 ng/mL). The K i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Orexin Receptor (OX Receptor)

Product Information

• Catalog No.: HY-134188
• CAS No.: 1628843-99-1
• Molecular Formula: C22H18F4N6O
• Molecular Weight: 458.41
• Purity: 98.06%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 6 mg/mL (13.09 mM); Clear solution
• Availability: In-stock

Source

Original product source