N-Acetylserine

Overview

N-Acetylserine (N-Acetyl-L-serine) is a complement pathway modulator targeting activated third complement protein ( C3b ) and an amino-terminal residue (an N-terminal acetylation modification group ). N-Acetylserine reacts with the exposed thioester group of C3b via its hydroxyl group, thereby blocking the covalent binding of glycerol to this thioester group. N-Acetylserine widely exists in soluble proteins of mammalian cells (accounting for approximately 80% of such proteins). N-Acetylserine has a blocking property that prevents direct Edman sequencing of proteins; deblocking is achievable through trifluoroacetic acid-catalyzed N→O acetyl migration followed by β-elimination. N-Acetylserine is suitable for sequencing of proteins with N-terminal acetylserine modification.

Application

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Product Information

• Catalog No.: HY-134222A
• CAS No.: 16354-58-8
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.13
• Purity: 98.0%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source