Zatebradine

Overview

Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC 50 value of 1.96 µM. Zatebradine blocks the slow inward current through human HCN1 , HCN2 , HCN3 and HCN4 channels , with IC 50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > HCN Channel

Product Information

• Catalog No.: HY-13422A
• CAS No.: 85175-67-3
• Molecular Formula: C26H36N2O5
• Molecular Weight: 456.57
• Purity: 98.00%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.48 mM); Clear solution
• Availability: In-stock

Source

Original product source