AZD3839 free base

Overview

AZD3839 is an orally available, selective, reversible inhibitor of the β-site amyloid precursor protein cleaving enzyme BACE1 that can cross the blood-brain barrier. AZD3839 inhibits recombinant human BACE1 with a K i =26.1 nM. AZD3839 inhibits A40 production in SH-SY5Y cells with an IC 50 of 4.8 nM. AZD3839 binds to BACE1 and reduces the Aβ amyloid produced by the cleavage of amyloid precursor protein (APP) by BACE1 and γ-secretase . AZD3839 can be used in the field of Alzheimer's disease research .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Beta-secretase

Product Information

• Catalog No.: HY-13438
• CAS No.: 1227163-84-9
• Molecular Formula: C24H16F3N5
• Molecular Weight: 431.41
• Purity: 99.97%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution
• Availability: In-stock

Source

Original product source