LY-404187 is a potent, selective and centrally active positive allosteric modulator of AMPA receptors , with the EC 50 s of 5.65, 0.15, 1.44, 1.66 and 0.21 µM for GluR1i , GluR2i , GluR2o , GluR3i and GluR4i , respectively. LY-404187 has therapeutic potential in a number of psychiatric disorders and neurodegenerative diseases.
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