Enpatoran

Overview

Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC 50 s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3 , TLR4 and TLR9 . Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo . Enpatoran can be used for both innate and adaptive autoimmunity blocking research .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR)

Product Information

• Catalog No.: HY-134581
• CAS No.: 2101938-42-3
• Molecular Formula: C16H15F3N4
• Molecular Weight: 320.31
• Purity: 99.87%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)
• Solubility: ≥ 2.44 mg/mL (7.62 mM); Clear solution
• Availability: In-stock

Source

Original product source