AM-1638

Overview

AM-1638 is an orally active full agonist of GPR40 ( EC 50 : 0.16 μM). AM-1638 increases the expression of antioxidant molecules ( HO-1 and NQO-1 ). AM1638 blocks Palmitate ( HY-N0830 )-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Free Fatty Acid Receptor

Product Information

• Catalog No.: HY-13467
• CAS No.: 1142214-62-7
• Molecular Formula: C33H35FO4
• Molecular Weight: 514.63
• Purity: 99.71%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 2.5 mg/mL (4.86 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source