Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4 -targeted HIV entry inhibitor with activity against HIV-1 replication . Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1 (NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate ( CAP ). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.
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