MD-222

Overview

MD-222 is the first-in-class highly potent PROTAC degrader of MDM2 . MD-222 consists of ligands for Cereblon and MDM2 . MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects. (Pink: MDM-2/p53 ligand ( HY-125858 ); Blue: Cereblon ligand ( HY-138793 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-134823
• CAS No.: 2136246-72-3
• Molecular Formula: C48H47Cl2FN6O6
• Molecular Weight: 893.83
• Purity: 98.03%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 5 mg/mL (5.59 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source