GSK716

Overview

GSK716 (A1AT modulator 1) is an orally active Z α 1 -antitrypsin (Z-A1AT) inhibitor with a pIC 50 of 8.3. GSK716 binds a cryptic Z α 1 -antitrypsin pocket, stabilizes monomeric folding intermediates, blocks polymerization, and increases monomer secretion. GSK716 acts on select sensitive α 1 -antitrypsin variants but fails to affect resistant variants. GSK716 can be used for the research of α 1 -antitrypsin deficiency and α 1 -antitrypsin deficiency-associated liver disease.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Serpin | Products > Signaling Pathways > Ser/Thr Protease

Product Information

• Catalog No.: HY-134858
• CAS No.: 2406205-61-4
• Molecular Formula: C21H23FN2O3
• Molecular Weight: 370.42
• Purity: 99.77%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (6.75 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source