Mitoxantrone

Overview

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

Application

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Product Information

• Catalog No.: HY-13502
• CAS No.: 65271-80-9
• Molecular Formula: C22H28N4O6
• Molecular Weight: 444.48
• Purity: 99.58%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution
• Availability: In-stock

Source

Original product source