Mitoxantrone dihydrochloride

Overview

Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity. Mitoxantrone dihydrochloride also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

Application

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Product Information

• Catalog No.: HY-13502A
• CAS No.: 70476-82-3
• Molecular Formula: C22H30Cl2N4O6
• Molecular Weight: 517.40
• Purity: 98.98%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
• Availability: In-stock

Source

Original product source