Milameline

Overview

Milameline (CI-979; RU35926) is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline has equal affinity for different subtypes of human muscarinic receptors with IC 50 of 1.3 µM for M1- , 1.1 µM for M2- , 1.5 µM for M3- , and 1.9 µM for M4-muscarinic receptors . Milameline has a higher affinity for sites [ 3 H]CMD ( IC 50 = 20 nM), than [ 3 H]QNB, ( IC 50 = 3059 nM). Milameline produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline can be used for the study of Alzheimer’s Disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR

Product Information

• Catalog No.: HY-135460
• CAS No.: 139886-32-1
• Molecular Formula: C8H14N2O
• Molecular Weight: 154.21
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source