KM91104

Overview

KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor ( IC 50 = 2.3 µM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV - TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Others | Products > Signaling Pathways > ATP Synthase | Products > Signaling Pathways > Toll-like Receptor (TLR)

Product Information

• Catalog No.: HY-135474
• CAS No.: 304481-60-5
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.26
• Purity: 98.06%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution
• Availability: In-stock

Source

Original product source