RWJ-60475

Overview

RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC 50 of 3.3 μM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase , interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-135477
• CAS No.: 204130-08-5
• Molecular Formula: C13H11BrNO7P
• Molecular Weight: 404.11
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source