NAS-181 free base

Overview

NAS181 free base is a potent and selective antagonist of rat 5-HT 1B receptor, with a K i of 47 nM. NAS181 free base shows 13-fold selectivity for r5-HT 1B over bovine 5-HT 1B receptor (K i =630 nM). NAS181 free base increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT 1B autoreceptors.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-135507A
• CAS No.: 205242-61-1
• Molecular Formula: C19H26N2O4
• Molecular Weight: 346.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source