RXP470.1

Overview

RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a K i of 0.2 nM against human MMP-12 . RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis , increased cap thickness, smaller necrotic cores, and decreased incidence of calcification.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-135517
• CAS No.: 891198-31-5
• Molecular Formula: C35H35BrClN4O10P
• Molecular Weight: 818.00
• Purity: 99.60%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source