Norfluoxetine

Overview

Norfluoxetine is the active metabolite of the antidepressant Fluoxetine ( HY-B0102 ); it is also a TREK-2 K 2 P potassium channel inhibitor . Norfluoxetine exhibits neuroimmunological activity, induces apoptosis in primary microglial cells, and inhibits the release of pro-inflammatory factors. Norfluoxetine inhibits high-threshold voltage-gated Ca 2+ currents in neurons with an EC 50 of 20.4 μM. Norfluoxetine can be used in research related to depression, ischemic stroke, and epilepsy.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Depression | Products > Disease Areas > Epilepsy | Products > Disease Areas > Ischemic Stroke | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-135556
• CAS No.: 83891-03-6
• Molecular Formula: C16H16F3NO
• Molecular Weight: 295.30
• Purity: 98.71%
• Storage: Store at room temperature, keep dry and cool. In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (8.47 mM); Clear solution
• Availability: In-stock

Source

Original product source