BD-1008

Overview

BD-1008 is a nonselective σ receptor antagonist with K i s against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 has an extremely low affinity for the D2 receptor ( K i = 1112 nM) and dopamine transporter (DAT) ( K i > 10,000 nM). BD-1008 significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 blocks the self-administration behavior of σ agonists.BD-1008 can be used for the study of addiction therapy that target the σ receptor.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Sigma Receptor

Product Information

• Catalog No.: HY-135608
• CAS No.: 138356-08-8
• Molecular Formula: C15H22Cl2N2
• Molecular Weight: 301.25
• Purity: 98.41%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (16.60 mM); Clear solution
• Availability: In-stock

Source

Original product source