Benoxaprofen

Overview

Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX , PGH2 synthase and cytochrome P-450 . Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms.

Application

Products | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Urticaria | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > COX | Products > Signaling Pathways > Lipoxygenase | Products > Signaling Pathways > PGE synthase

Product Information

• Catalog No.: HY-13568
• CAS No.: 51234-28-7
• Molecular Formula: C16H12ClNO3
• Molecular Weight: 301.72
• Purity: 99.03%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source