A2764 dihydrochloride

Overview

A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K + channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels ( IC 50 =6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception.

Application

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Product Information

• Catalog No.: HY-135809
• CAS No.: 861038-72-4
• Molecular Formula: C15H21Cl3N2O
• Molecular Weight: 351.70
• Purity: 99.05%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (5.91 mM); Clear solution
• Availability: In-stock

Source

Original product source