GNE-1858

Overview

GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC 50 s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MAP4K

Product Information

• Catalog No.: HY-135892
• CAS No.: 2680616-96-8
• Molecular Formula: C21H26F2N8
• Molecular Weight: 428.48
• Purity: 99.23%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2 mg/mL (4.67 mM); Clear solution
• Availability: In-stock

Source

Original product source