P2X3 antagonist 34

Overview

P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC 50 s of 25 nM, 92 nM and 126 nM for human P2X3 , rat P2X3 and guinea pig P2X3 receptors , respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2X Receptor

Product Information

• Catalog No.: HY-135976
• CAS No.: 2417288-67-4
• Molecular Formula: C24H26F2N4O3
• Molecular Weight: 456.49
• Purity: 99.44%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (5.48 mM); Clear solution
• Availability: In-stock

Source

Original product source