bpV(phen)

Overview

bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC 50 s of 38 nM, 343 nM and 920 nM for PTEN , PTP-β and PTP-1B , respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway ( IL-12 , IFNγ). bpV(phen) can also induce cell apoptosis , and has anti-angiogenic and anti-tumor activity.

Application

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Product Information

• Catalog No.: HY-136065
• CAS No.: 42494-73-5
• Molecular Formula: C12H8KN2O5V
• Molecular Weight: 350.24
• Purity: 98.0%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source