YM-244769

Overview

YM-244769 is a potent, selective and orally active Na + /Ca 2+ exchanger ( NCX ) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current ( Ca 2+ entry mode), with IC 50 s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Na+/Ca2+ Exchanger

Product Information

• Catalog No.: HY-136182A
• CAS No.: 838819-70-8
• Molecular Formula: C26H22FN3O3
• Molecular Weight: 443.47
• Purity: 99.22%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (4.69 mM); Clear solution
• Availability: In-stock

Source

Original product source