TAN-452

Overview

TAN-452 is an orally active, selective peripherally acting δ-opioid receptor (DOR) antagonist with a K i of 0.47 nM and a K b of 0.21 nM. TAN-452 is an antagonist for μ-opioid receptor ( MOR ; K i =36.56 nM and K b =9.43 nM) and κ-opioid receptor ( KOR ; K i =5.31 nM and K b =7.18 nM). TAN-452, a derivative of Naltrindole, demonstrates low brain penetrability and attenuates morphine-induced side effects without affecting pain control.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Pain | Products > Disease Areas > Obesity | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Opioid Receptor

Product Information

• Catalog No.: HY-136208
• CAS No.: 892039-23-5
• Molecular Formula: C29H30N2O5
• Molecular Weight: 486.56
• Purity: 99.16%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.14 mM); Clear solution
• Availability: In-stock

Source

Original product source