ML417

Overview

ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC 50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Depression | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-136390
• CAS No.: 1386162-69-1
• Molecular Formula: C22H25N3O3
• Molecular Weight: 379.45
• Purity: 99.39%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution
• Availability: In-stock

Source

Original product source