SJF-0628

Overview

SJF-0628 is a PROTAC degrader of BRAF mutants, with a DC 50 of 6.8 nM against BRAF V600E . SJF-0628 induces the ubiquitination and degradation of BRAF mutants in various cancer cell lines. SJF-0628 reduces pMEK and pErk levels. SJF-0628 exhibits antitumor activity. SJF-0628 can be used in research on colorectal cancer , melanoma, lung cancer , and triple-negative breast cancer . (Pink: B-Raf V600E ligand ( HY-12057 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-W803227 )).

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Raf | Products > Signaling Pathways > MEK | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-136420
• CAS No.: 2413035-41-1
• Molecular Formula: C51H57F2N9O7S2
• Molecular Weight: 1010.18
• Purity: 99.90%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 4 mg/mL (3.96 mM); Clear solution
• Availability: In-stock

Source

Original product source