BMS-986251

Overview

BMS-986251 is an orally active and selective RORγt inverse agonist with an EC 50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC 50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod -induced ( HY-B0180 ) models (preclinical models of psoriasis).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROR | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-136527
• CAS No.: 2460133-35-9
• Molecular Formula: C30H29F8NO5S
• Molecular Weight: 667.61
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source