Aftin-5

Overview

Aftin-5 is an inducer for Amyloid-β 42 ( Aβ42 ). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC 50 s of 180, 194, 178 and 150 μM, respectively.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-136674
• CAS No.: 1461717-05-4
• Molecular Formula: C19H26N6O
• Molecular Weight: 354.45
• Purity: 99.70%
• Storage: Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.67 mg/mL (4.71 mM); Clear solution
• Availability: In-stock

Source

Original product source