TD114-2

Overview

TD114-2 (cmpound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β ( GSK-3β ) ( IC 50 =48 nM). TD114-2 is associated with the hydrogen bond formation of arginine 141 (ARG141) specific to GSK-3β , an amino acid that is often a negatively charged residue in other kinases, which determines the high selectivity of GSK-3β . TD114-2 can be used in the study of diabetes, neurodegenerative diseases and other diseases associated with GSK-3β .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > GSK-3

Product Information

• Catalog No.: HY-136679
• CAS No.: 436866-52-3
• Molecular Formula: C30H31N3O6
• Molecular Weight: 529.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source