ZXX2-77

Overview

ZXX2-77 is a cyclooxygenase-1 ( COX-1 ) selective inhibitor belonging to the benzenesulfonylanilide class of compounds. It is reported as a novel analgesic that does not cause gastric damage. ZXX2-77 has a weak analgesic effect but exhibits potent COX-1 inhibitory activity in vitro. The low oral absorption rate of ZXX2-77 leads to its weak analgesic effect in vivo. At a dose of 30 mg/kg, the maximum plasma concentration of ZXX2-77 (1.2 mM) did not reach its COX-1 IC50 value (3.2 mM). In contrast, its derivative ZXX2-79, although weaker in vitro COX inhibitory activity, is better absorbed, exhibits stronger analgesic effect and hardly causes gastric damage. These findings suggest that ZXX2-77 and its derivatives as COX-1 selective inhibitors may become effective analgesics that do not cause gastric damage.

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Others | Products > Signaling Pathways > COX

Product Information

• Catalog No.: HY-136720
• CAS No.: 304913-22-2
• Molecular Formula: C13H13ClN2O2S
• Molecular Weight: 296.77
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source