Tuxobertinib

Overview

Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows K D s of 0.2, 0.76, 13 and 1.2 nM for EGFR , HER2, BLK and RIPK2 , reapectively. Anticancer activity.

Application

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Product Information

• Catalog No.: HY-136789
• CAS No.: 2414572-47-5
• Molecular Formula: C29H29ClN6O4
• Molecular Weight: 561.03
• Purity: 99.88%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: 2.08 mg/mL (3.71 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source