1α-Hydroxyvitamin D5

Overview

1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA , the phosphorylation of FAK , and the gene expression of MLCK and ET-1 , while activating the anti-inflammatory pathway of IL-1β/COX-2 . 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Myosin | Products > Signaling Pathways > FAK | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > COX

Product Information

• Catalog No.: HY-13692
• CAS No.: 187935-17-7
• Molecular Formula: C29H48O2
• Molecular Weight: 428.69
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source