BODIPY-Cyclopamine

Overview

BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened ( SMO ) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > Smo

Product Information

• Catalog No.: HY-137115
• CAS No.: 334658-24-1
• Molecular Formula: C49H70BF2N5O4
• Molecular Weight: 841.92
• Purity: 98.91%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (2.97 mM); Suspended solution
• Availability: In-stock

Source

Original product source