(S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α 4 β 2 nAChRs than for α 7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction.
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