WH-10417-099

Overview

WH-10417-099 is a CRBN -based PROTAC multi-kinase degrader that induces the degradation of the maximum number of unique kinases (over 125 unique kinases, such as CSNK1E and PI3Kγ ) simultaneously. WH-10417-099 induces protein degradation via the ubiquitin biotinylation ( E-STUB ) pathway, exhibits synergistic effects with SB-405483 ( HY-W1135319 ). The E3 ligase ligand and linker of WH-10417-099 can form the conjugate Pomalidomide 4'-PEG5-acid ( HY-131647 ). (Pink: PI3Kγ ligand ( HY-168319 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-115384 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Casein Kinase

Product Information

• Catalog No.: HY-137340
• CAS No.: 2769753-42-4
• Molecular Formula: C52H62N8O13S
• Molecular Weight: 1039.16
• Purity: 98.14%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source