SB1-G-187

Overview

SB1-G-187 is a multi-target kinase PROTAC degrader with activity against various kinases including GCK , YES1 , IRAK1 and LYN . SB1-G-187 induces degradation of target kinases via a p97 -dependent pathway, and forms ternary complexes with CRBN and specific functional kinases. SB1-G-187 can be used in tumor-related research. (Pink: Lyn and Yes and IRAK1 ligand ( HY-125142 ); Blue: Cereblon ligand ( HY-A0003 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcr-Abl | Products > Signaling Pathways > MAP4K | Products > Signaling Pathways > Cyclin G-associated Kinase (GAK) | Products > Signaling Pathways > CDK | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Src | Products > Signaling Pathways > IRAK

Product Information

• Catalog No.: HY-137342
• CAS No.: 2769753-18-4
• Molecular Formula: C52H54F3N9O10
• Molecular Weight: 1022.03
• Purity: 98.70%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: 5 mg/mL (4.89 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source