CG428

Overview

CG428 is a potent and selective CRBN-dependent tropomyosin receptor kinase ( TRK ) PROTAC degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 TPM3-TRKA fusion protein in KM12 colorectal carcinoma cells ( DC 50 = 0.36 nM) and inhibits downstream PLCγ1 phosphorylation ( IC 50 = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (Kd = 1 nM, 28 nM and 4.2 nM, respectively). CG428 can be used for the research of colorectal carcinoma. (Pink: Trk Receptor ligand ( HY-118271 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-W067489 )).

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-137465
• CAS No.: 2412055-93-5
• Molecular Formula: C43H43FN10O6
• Molecular Weight: 814.86
• Purity: 98.18%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source