PROTAC BRAF-V600E degrader-2

Overview

PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with K d s of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth. (Pink: B-Raf V600E ligand ( HY-184546 ); Blue: Cereblon ligand ( HY-W087383 ); Black: linker ( HY-W074340 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Raf

Product Information

• Catalog No.: HY-137488
• CAS No.: 2417296-82-1
• Molecular Formula: C42H39F2N7O8S
• Molecular Weight: 839.86
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source