Sitagliptin phosphate (Standard)

Overview

Sitagliptin (MK-0431) phosphate (Standard) is the analytical standard of Sitagliptin phosphate ( HY-13749A ). This product is intended for research and analytical applications. Sitagliptin phosphate is an orally active and highly selective DPP4 inhibitor with an IC 50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 ( GLP-1 ) and glucose-dependent insulinotropic peptide ( GIP ) by competing inhibition mechanism ( Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4 . Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > GLP Receptor | Products > Signaling Pathways > Dipeptidyl Peptidase | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > PKA

Product Information

• Catalog No.: HY-13749AR
• CAS No.: 654671-78-0
• Molecular Formula: C16H18F6N5O5P
• Molecular Weight: 505.31
• Purity: 99.82%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source