Sitagliptin-d 4 phosphate

Overview

Sitagliptin-d 4 phosphate (MK-0431-d 4 ) is the deuterium labeled Sitagliptin phosphate ( HY-13749A ). Sitagliptin phosphate is an orally active and highly selective DPP4 inhibitor with an IC 50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 ( GLP-1 ) and glucose-dependent insulinotropic peptide ( GIP ) by competing inhibition mechanism ( Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4 . Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes.

Application

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Product Information

• Catalog No.: HY-13749AS
• CAS No.: 1432063-88-1
• Molecular Formula: C16H14D4F6N5O5P
• Molecular Weight: 509.33
• Purity: 99.48%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source