Sitagliptin hydrochloride

Overview

Sitagliptin (MK-0431) hydrochloride is an orally active and highly selective DPP4 inhibitor with an IC 50 value of 19 nM. Sitagliptin hydrochloride blocks the degradation of glucagon-like peptide-1 ( GLP-1 ) and glucose-dependent insulinotropic peptide ( GIP ) by competing inhibition mechanism ( Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin hydrochloride can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4 . Sitagliptin hydrochloride shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin hydrochloride can be used for the study of 1-type and 2-type diabetes.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Dipeptidyl Peptidase | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > PKA | Products > Signaling Pathways > GLP Receptor

Product Information

• Catalog No.: HY-13749E
• CAS No.: 486459-71-6
• Molecular Formula: C16H16ClF6N5O
• Molecular Weight: 443.77
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source