Sitagliptin (Standard)

Overview

Sitagliptin (Standard) is the analytical standard of Sitagliptin ( HY-13749 ). This product is intended for research and analytical applications. Sitagliptin is an orally active and highly selective DPP4 inhibitor with an IC 50 value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 ( GLP-1 ) and glucose-dependent insulinotropic peptide ( GIP ) by competing inhibition mechanism ( Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4 . Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes.

Application

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Product Information

• Catalog No.: HY-13749R
• CAS No.: 486460-32-6
• Molecular Formula: C16H15F6N5O
• Molecular Weight: 407.31
• Purity: 95%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source